Model to Predict Process Parameters for Scale-Up of Hot Melt Extrusion Process
Summary: 鈥婽echnology transfer and scale-up from a laboratory-scale to commercial-scale HME process聽require several in-depth empirical studies during product development. Without prior聽calculations and in-silico scale-up models, this can consume large amounts of drug substance.
Download the technical note to learn about聽a mathematical approach to scale-up of hot melt extrusion (HME)聽from laboratory-scale to production-scale,聽applying the quality by design聽principle.聽By using this approach,聽technology聽transfer聽is聽successful in meeting the quality target product profile while consuming a minimal amount of the drug substance.